![]() ![]() Methylene blue (MB 20 µg/ml) added 3 min after NaCN restored contraction and i transient amplitudes, systolic i, E m, AP amplitude, APD 50, APD 90, I Ca, depolarization-activated K + currents, ΔΨ m, and O 2 NaCN did not affect cellular adenosine triphosphate levels but depolarized mitochondrial membrane potential (ΔΨ m) and increased superoxide (O 2 In addition, NaCN depolarized resting membrane potential ( E m), reduced action potential (AP) amplitude, prolonged AP duration at 50% (APD 50) and 90% repolarization (APD 90), and suppressed depolarization-activated K + currents but had no effect on Na +-Ca 2+ exchange current ( I NaCa). ![]() NaCN (100 µM) exposure for 10 min significantly decreased contraction and intracellular Ca 2+ concentration ( i) transient amplitudes, systolic but not diastolic i, and maximal L-type Ca 2+ current ( I Ca) amplitude, indicating acute alteration of i homeostasis largely accounted for the observed excitation-contraction abnormalities. All non-essential skin and eye contact should be avoided.In adult left ventricular mouse myocytes, exposure to sodium cyanide (NaCN) in the presence of glucose dose-dependently reduced contraction amplitude, with ~80% of maximal inhibitory effect attained at 100 µM. Methylene Blue should not be ingested in larger quantities as it may lead to side-effects such as Hypertension, Dizziness, Headache, Fever, skin staining, Vomiting, abdominal pain, bladder irritation, urine discoloration, anemia. Nerve Fiber: Used in staining of nerve fiberĪquaculture: Use to prevent and treat whitespot in various fish species Staining: Used in endoscopic polypectomy to stain tissue which tells how many more tissues needs to be removedīone Cement: In orthopedic operations, it is used to distinguish between native bone and cement With Light: When combined with light, it is used to treat Hepatitis CĬuring Cyanide Poisoning: In large doses, it is also used as an antidote to potassium cyanide poisoning (tested method) Uses include:Ĭolourant: Staining of products and as a marker dye Methylene Blue 1 % solution has many uses majorly in medical purpose and aquaculture for treatmenrt of whitespot. ![]()
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